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Eating right aids recovery from illness, healthy living

Getting to eat right after being diagnosed with an ailment that limits the types of food a patient can eat can be very frustrating, a six years diabetic patient, Ajoke Olusola, says.

Mrs Olusola was advised by her physician to change her dietary pattern after being diagnosed with diabetes.

“I was advised to stop eating some food; majorly carbohydrates, fatty foods and carbonated drinks. Since then, my dietary pattern changed,” she said.

“To get better and reduce my blood sugar level, I was told to do away with some food. Unfortunately most of those foods were my best. It was not easy at first but I had to talk myself into complying. I knew for my medication to work effectively, I need to comply,” she said.

Many people eat without following a healthy dietary pattern. Healthy diet entails eating food from all the sub-groups with the right amount of nutrients.

Promise Hammed, a woman who had high blood sugar during pregnancy, said she started watching her dietary pattern from when she was young. This is because she was aware she had the tendency to be diabetic because her parents were.

“I know it is hereditary so I watched what I ate. I got extra careful after having high blood sugar in pregnancy. Blood sugar test during pregnancy is one of the routine tests for pregnant women and I have continued the test. This helps doctors to quickly detect my case and since then I have been living on a strict dietary pattern,” she said

Another patient, a breast cancer survivor who asked not to be named, told PREMIUM TIMES she had to change her diet after she was diagnosed with the disease.

Her doctors advised her that to win the battle against the disease, she needed to change her dietary pattern.

“I was told to minimise my sugar intake. This is to help reduce the multiplication of the cancer cells because they thrive more on sugar. Unfortunately, that has been very difficult and cost intensive because most of the regular foods we take are sugar-based. All the normal stable foods in the market have one form of sugar, especially carbohydrates which are cheaper and easy to come by.

“I have been living more on vegetables, fruits, and natural foods with less sugar, protein, legumes, among others. The problem however, is that these foods are expensive. Keeping up can be a bit challenging because of the perishable nature of most of these foods. They cannot be bought in bulk and stored. The epileptic power supply is another issue because you cannot buy and keep when you have the money,” she said.

She said keeping to the diet has made feeding expensive.

“This has an indirect effect on the management of illness in the country. A situation whereby one has spent all they have on treatment and they are expected to keep looking for more just to sustain a feeding lifestyle is very difficult and as such, the person tends to make do with the available. This can have a negative effect on the treatment or trigger a worse health condition,” she said.

A dietician, Sarah Abagai, who spoke with PREMIUM TIMES on healthy dietary pattern, said people do not need to wait until they are diagnosed of disease before they take care of their health.

She explained that the dietary pattern for each ailment differs according to diagnosis.

“While it is quite difficult to strictly categorise the types of food to be consumed by diagnosed patients, it is advisable to tell people to eat healthy always. Various food are restricted to people with various aliments.

“However, consumption of less fat, less sugar, reduced salt intake, (unless otherwise medically advised), more of natural foods such as fresh fruits, vegetables, among others can go a long way to help,” she said.

Mrs Abagai attributed lots of diseases to the lifestyle of people.

“Dietary pattern is an important aspect of people’s lifestyle which affects the health. It is important to understand the type of career one keeps to determine what is being consumed.

“This is because stress affects the body metabolism, which can lead to common issues of high blood cholesterol, high level blood glucose and high blood pressure. All these are fallouts of high stress life,” she added.

Mrs Abagai also advised Nigerians to introduce more herbs into their diet.

Some herbs that can boost your immune system, help you stay fit

1. Ginger

Ginger is an underground stem, known as antioxidant and anti-inflammatory agent. Ginger can be used as treatment for nausea, to fight fungal infections, protect against stomach ulcer and ease menstrual pains. It may inhibit cancer growth, regulate blood sugar, relief joint and muscle pains, lower cholesterol, reduce bacterial infections, ease inflammation and promotes proper digestion.

2. Galic

This is a specie of onions. It contains vitamins C and B6, manganese, allicin, selenium and other antioxidants. Researches suggest that garlic may be effective against high blood sugar, cardiovascular diseases, cholesterol, cold and some cancers.

3. Cinnamon

Cinnamon is a spice obtained from the inner bark of several tree species from the genus Cinnamomum. Cinnamon has antioxidant properties. It can lower blood sugar levels, reduce heart disease risk factors, and has a plethora of other impressive health benefits.

4. Raw tomatoes

The tomato is the edible, often red fruit. Tomatoes are vegetable and better eaten raw. It is a good source of vitamin c, potassium, vitamin K1, folate (B9) lycopene, beta-carotene, naringenin, chlorogenic acid. Benefits include treatment of cardiovascular diseases, blood sugar, skin care, etc.

5. Coriander leaves

These an be used to garnish food. Health benefit of coriander includes treatment of skin inflammation, cholesterol, diahorrea, mouth ulcer, anaemia, indigestion, menstrual disorders, and blood sugar problems.

Other beneficial herbs include Turmeric, Cloves, Onions, chilli pepper, palsy.

Article source: https://www.premiumtimesng.com/health/health-interviews/269806-eating-right-aids-recovery-from-illness-healthy-living.html

John, Deb Boesen to speak on living healthy lifestyle

Community Health Seminars will feature Deb and John Boesen for Part 2 of their “Your Body is Made to Heal Itself” series. They will speak at 7 p.m. Thursday in Room 225 of Peters Science Hall on the Kansas Wesleyan University campus.

The Boesens will discuss how to improve digestion, the importance of minerals, foods to build a healthy body and other pertinent areas.

The two will answer questions following the presentation.

The talks are free and open to the public, with donations accepted.

For more information, call Lou Tryon at 827-8053.

Article source: http://www.salina.com/news/20180525/john-deb-boesen-to-speak-on-living-healthy-lifestyle

Free training offered to future healthy living leaders

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Article source: http://www.tucsonnewsnow.com/story/38243496/free-training-offered-to-future-healthy-living-leaders

Healthy Living: Stress and the Balloon Animal, with Mike Bork – Fairbanks Daily News

Join us in becoming informed about up-to-the-minute medical knowledge on human health (presented so that it can be understood without being doctors ourselves!) with local experts. Tonight: Mike Bork, Stress Management Consultant and Coach

Article source: http://www.newsminer.com/calendar/healthy-living-stress-and-the-balloon-animal-with-mike-bork/event_35d46718-2648-11e8-b6b3-5cb9017b3617.html

Healthy Living: Deadly Infections Fight

The World Health Organization, National Institutes of Health, and the Centers for Disease Control call multidrug resistant bacteria one of the biggest threats to public health, with an estimated 700,000 people dying worldwide every year.

When the bacteria was killing a San Diego man, his desperate wife suggested a treatment that seemed really out there until it worked.

Courtney Hunter explains how in Healthy Living.

Dr. Schooley says phages would probably be studied as a combination therapy, and Tom was taking powerful antibiotics along with the phages.

Several national health agencies are considering clinical trials now.

UC San Diego hopes to start one in a few months.

 


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Article source: http://www.9and10news.com/2018/05/25/healthy-living-deadly-infections-fight/

3 Super Simple Strategies to Stay Healthy and Happy This Summer

LOS ANGELES, CA - MAY 24:  Jasmine Tookes (C) and guests attend Victorias Secret and Tone It Up Host a Slay Then Rosé workout with Angel Jasmine Tookes on May 24, 2018 in Los Angeles, California.  (Photo by Tommaso Boddi/Getty Images for Victoria's Secret)

Who else is stoked for Summer? It might be our favorite season, but we sometimes need a little help keeping on the healthy track. Luckily, we picked up a few tips for staying healthy this Summer courtesy of some of our favorite fitness inspirations: Katrina and Karena of Tone It Up and Victoria’s Secret model Jasmine Tookes at a recent Victoria Sport workout event in LA. We suggest putting these tips into practice ASAP.

Find a Workout Buddy

In the warmer months, it may be tempting to just chill by a pool rather than fit in those reps at the gym, but both Katrina and Karena agree on their favorite way to stay motivated: grab a workout buddy! Karena recommends encouraging your friends and family to go for walks or hikes. If you can find a fitness BFF, check in with them daily to see what their workout is. Katrina adds, “Be each others’ best encouragement.” And of course, partner workouts are always fun!

Chose This Vegetable to Debloat

Katrina’s tip for staying debloated? Eating asparagus with your dinner. Asparagus encourages digestive health by stimulating the growth of good bacteria in your body. You can check out our healthy recipes featuring asparagus here.

Keep Water on Hand

During long weekends, Jasmine always makes sure to stay hydrated. “Even if you’re partying with friends, just keep water on hand to stay hydrated.” We can cheers to that.

Article source: https://www.popsugar.com/fitness/Summer-Healthy-Living-Tips-44883137

Mojo and Microbiome:: Part 1

We have a little treat for you in the next 3 weeks.  I am so pleased to introduce my dear friend Allison Hopkins to contribute as a guest blogger.  Allison and I have known each other for over 11 years – she is my go to when I want to hash out the virtues of grass fed vs organic or really anything else in life.  We were colleagues for 9 years when I worked in the Biotech industry. We covered the State of Maine together and have clocked hundreds of hours in the car together.

Let me tell you a little bit about long car rides with curious minds… they discuss a lot.  Allison and I are similar in a lot of ways – we love data, we love analyzing that data, and we love talking about it.

Allison has studied immunology molecular biology at the master’s level and is the best person I know who can take something super complex like Polymerase Chain Reaction (PCR) and break it down so anyone can understand it.

Allison has always lived a healthy lifestyle – she is the one that first warned me in my early twenties of the dangers of chemicals in our cleaning and personal care products.  Recently she has invested an incredible amount of time learning about nutrition and exercise – she has recently become Precision Nutrition Certified and has embraced our Habits for Massive Impact, starts her day each morning with our Morning Mojo and works out 3 times per week with our at home workout guide.

I am so excited for you to learn from Allison in this 3 part blog series on our Morning Mojo from a scientific perspective.  I have had the privilege of learning from her for years and I am excited to share her brain with you!

Allison has experienced first hand the benefits of starting her day with the Morning MoJo and in this blog series, she is going to share with us her research with WHY this is such a powerful drink for health.  She will share with us the incredible benefits to the Microbiome, Alkalization, and Hydration.

I have known Mike Paige Wilcox for many years (oh the stories I could share…), and as Paige notes, we have enjoyed many inquisitive conversations with each other pondering various curiosities.  The latest of which is the amazing attributes of the Morning Mojo, which is a concoction of apple cider vinegar (ACV), freshly squeezed lemon juice, and freshly grated ginger.

You have probably seen a recent resurgence of these olde timey concoctions.  Some of us may be familiar with the idea of drinking ACV, lemon juice, or both from our grandparents.  So what is it about the come back around these of things, and do they actually work?

Well, I can tell you that I’ve been drinking the morning mojo daily since last October, and I’ve noticed a few benefits for myself.  This past winter was brutal for cold and flu, and I’m happy to say that I made it through the entire winter healthy, despite airline travel, days trapped in conference rooms and exposure to the kids in my life.  Additionally, my allergies to my cats seem to have subsided, and so far spring allergies aren’t bothering me at all.

So is all of this due to drinking morning mojo?  Perhaps!

I’ve been doing a lot of reading on nutrition over the past several months, and there are three common themes that I am encountering, all of which lead us to some answers about the benefits of morning mojo. They are Alkalization, Gut Biome health, and Hydration. Over this and two additional blog posts I will share some of the interesting information that I have discovered about these three influences on our health and well being, and why I think they provide some insight into why morning mojo is an excellent way to start your day and maintain a healthy and energetic body.

To kick off this series I am going to start with the Microbiome of the gut.  You might not think of the term “gut” as a scientific term, yet it’s common to hear the phrase “gut biome” when referring to the relatively new interest in the microbes that live within our digestive system.  “Gut” generally refers to the stomach and intestines. The microbiome is a term referring to a population of bacteria, viruses and fungi, and their associated genetics, in an environment (3). There are microbiomes in all kinds of environments including other parts of our bodies such as the microbiome of the skin, but can also refer to bacterial populations outside of the body, such as the microbiome of a wetland.

The microbiome has been a topic that has been receiving all kinds of attention in the research arena across many areas of study including the area of nutrition.  In fact, National Institute of Health (NIH) has engaged in a 5 year study to better understand the bacterial population of our gut and its association with disease (3).

Bacteria are very prevalent in our environment and in our body.  We often associate bacteria as something bad. We spray hand sanitizer and antibacterial cleaners all around us to prevent us from these seemingly harmful critters.  But a lot of the bacteria in and on our body are there to help us out and we should think twice before trying to kill all of them.

In fact, there is at least as many bacterial cells in our bodies as our own human cells (5)!  And the majority of those bacterial cells populate the colon and are associated with digestive health.  Our gut bacteria play a much bigger role than you may realize. The bacteria in our gut are directly involved with the breakdown of food, gaining access to all of the amazing nutrients so that our body can use them to keep us strong and energized.  But the population of bacteria in our gut can vary with good and bad bacteria, and the way that we eat can influence the proportion of beneficial bacteria and those who have their own interests in mind over ours.

Bacteria have been on this planet longer than we have and they have developed a very keen ability to survive.  They are actually able to influence signals that are sent to our brain that tell us that we’re hungry and cause us to crave foods that support their survival.  This is the root of sugar addiction. Eating refined sugar causes changes in our gut bacteria, resulting in bacteria that need sugar to survive (2). When our gut bacteria gets out of balance we’ll find ourselves craving unhealthy foods.  On the other hand, when we develop a habit of eating whole, healthy foods our gut bacterial population will change in response, and before long you will probably find yourself craving an apple over a candy bar or bag of potato chips.

TRUTH BOMB – our gut bacteria is responsible for our cravings and we have the ability to train our gut to crave the good stuff!

The morning mojo is a great way to jump start or maintain your efforts in developing healthy, whole food eating habits by supporting beneficial bacteria in your gut that will crave other healthy foods.  Consuming lemon juice and ACV helps to support a healthy gut environment through their role as a prebiotic, not to be confused with probiotics. Probiotics contain the healthy bacteria that support our gut health, and include foods like yogurt, miso, kimchi and sauerkraut.  A prebiotic is a food that beneficial gut bacteria eat, and in the case of ACV and lemon juice is found in the pectin. The pectin comes from the apple skins and from the pulp of the lemon, so when you make your morning mojo be sure to get the pulp out of the lemon too.

Apple cider vinegar also helps to increase stomach acid and delay gastric emptying, providing additional time and help breaking down the food in your stomach.  This helps to aid in digestion and absorption of nutrients from food. Additionally, acid reflux is thought to be due to low acid content in the stomach, so drinking ACV and lemon water can help to reduce these types of symptoms if you experience them.

Although not directly associated with your gut’s microbiome it is worth noting that ACV is also known for decreasing the release of histamines (4).  Histamines are chemicals released by our bodies in response to an intruding particles like pollin or pet dander. We typically respond to our allergic reactions with over the counter antihistamines, which often leave us feeling groggy.  Apple Cider Vinegar naturally reduces the release of histamines, thus reducing the overproduction of mucus in response, and therefore relieving those unpleasant symptoms.

There are many believers in the benefits of ACV and lemon water.  Some recommend drinking it in warm water to assist with the ramp up your digestive juices first thing in the morning.  Others recommend drinking ACV about a ½ hour before each meal. Personally, I prepare a concentrate using the Wilcox Wellness Fitness Morning Mojo recipe and then combine 12oz of water with 2T of concentrate each morning.  If the taste is too strong at first, consider starting with 1T of concentrate in your water and working your way up over time.

From Paige:  She’s great, isn’t she?  I love how she is able to take complex scientific information and give us just the chunks that we care about in a way that is important to us.

I think it is absolutely amazing that our gut bacteria has control over our cravings and we have the ability to change it to crave the good stuff.

We hope this has inspired you to give our Mojo a try.  It certainly is an acquired taste – I think it is absolutely delicious – like a fancy lemonade but a lot of our clients absolutely hate it at first.  (They do grow to love it!)

If you are interested in giving it a try, you can download our recipe here:

click here to get your mojo recipe

Let us know what you think!

Can’t wait to share next week’s post with you on the benefit of alkalization in the body.

Enjoy!

Paige Allison

Inspired to give the Morning Mojo a try – download our recipe here:
https://wilcoxwellnessfitness.lpages.co/mojo/

Want more support?  Join our free Facebook Group:
https://www.facebook.com/groups/WilcoxHealthyLiving/
Join our free private FaceBook Group – Healthy Living with Wilcox Wellness Fitness to connect with us live.  Daily we post all things healthy living – pro tips for healthy living, recipes, and weekly workouts for you to do at home.  We will answer any question you post and we encourage you get involved in the discussion.

Don’t miss another post.  Join our mailing list here:
http://www.wilcoxwellnessfitness.com/keep-in-touch.html

Article source: http://bangordailynews.com/link/mojo-and-microbiome-part-1/

Belmar Cares Hosts Evening Focused on Healthy Living … and ‘In the Pink’ Fun

BELMAR, NJ — Some 80 women gathered at the Taylor Pavilion yesterday for an evening of inspiring conversation about living healthy — and a bit of pampering — during the fourth annual “In the Pink” Health Fair, hosted by Belmar Cares.

The breast cancer support group brought together a wide spectrum of medical and other professionals who presented the enlightening program on May 23. “If we can save one life with ‘In the Pink,’ then it’s a worthwhile endeavor,” said Claire Deicke, an event organizer who founded the group 10 years ago.

Guest speaker Denise Johnson Miller, M.D., medical director of breast surgery for Neptune-based Meridian Cancer Care, gave participants an overview of recent advances in breast cancer detection, and stressed the importance of genetics and knowing your family’s history of the disease.

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Chiropractor Veera Gupta of Wall focused on how a healthy diet is tantamount to good health, while Kate Walters of Sweet Tease Tea Room and Café offered information on the healing powers of tea and how sitting down for a cup of tea can reduce stress for many.

Liz Balogh of Lin Linen’s explained the mission of her volunteer group in supporting women with cancer by creating personal healing sanctuaries that promote a positive mind, body, and spirit connection crucial to the healing process.

And yoga instructor Brenda Yarnold got the room moving with a chair yoga demonstration.

As for the “pink” pampering, attendees were also treated to pink manicures by Carol Cupoli and sister Camille Witkowski, both of Belmar, and Belmar Council President Jennifer Nicolay, as well as pink hair-painting by Teresa Vassallo of Vanity 18 Hair Salon in Lake Como.

Pink baked treats were served up as well, courtesy of the Belmar Woman’s Club.

TAPinto Belmar/Lake Como is Belmar and Lake Como’s only free daily newspaper. Accredited by the New Jersey Press Association, it is the official electronic newspaper of both municipalities. As a locally owned news organization, TAPinto through its advertisers is able to publish online, objective news 24/7 at no charge. Sign up for its free daily e-News, and follow it on Facebook and Twitter.

Download the free TAPinto App! Click here for Android - Click here for iOS to get news as it is happening.

 

Article source: https://www.tapinto.net/towns/belmar-slash-lake-como/articles/belmar-cares-hosts-evening-focused-on-healthy-liv

Healthy Living: Intermittent Fasting

Nutritionist and wellness coach, Deborah Enos stopped by Q13 to share her thoughts on intermittent fasting and some healthy options if it’s something you’ve considered trying for either weight-loss, digestion or inflammation.

Since our on-air segment was limited to just a few minutes, below are some additional notes Deborah used as a guide from Dr. Josh Axe, a wellness physician

What is intermittent Fasting?

Intermittent fasting is hardly a new concept. It’s been used for centuries during times when food was scarce and it even plays a central role in many major religions. In fact, once a year, Muslims observe Ramadan, a month of fasting from dawn until sunset.

It’s difficult to define intermittent fasting as there’s not just one correct method for how to fast. In fact, there are many different variations of intermittent fasting that are used around the world. Each follows a different eating pattern that is often strictly adhered to in order to achieve physical or even spiritual results.

How does it work?

The extensive research on the concept of intermittent fasting suggests it functions in two different ways to improve various facets of health. First, intermittent fasting results in lowered levels of oxidative stress to cells throughout the body.

Second, practicing fasting improves your body’s ability to deal with stress at a cellular level. Intermittent fasting activates cellular stress response pathways similar to very mild stressors, acting as mild stimulants for your body’s stress response. As this occurs consistently, your body is slowly reinforced against cellular stress and is then less susceptible to cellular aging and disease development.

Who should avoid intermittent fasting?

If you suffer from low blood sugar, for example, going without eating all day may lead to dangerous drops in blood sugar causing symptoms like shakiness, heart palpitations and fatigue. If you have diabetes, it’s best to work with your doctor to determine if intermittent fasting is right for you.

If you have a history of eating disorders, this may also not be ideal for you as it may encourage unhealthy behaviors and trigger symptoms. If you are a child or teenager and still growing, intermittent fasting is not recommended either.

Those who are sick may also want to reconsider intermittent fasting as it can deprive your body of the steady stream of nutrients that it needs to heal and get better.

Intermittent fasting for women? Of course, those who are pregnant should also avoid intermittent fasting and focus instead on a nutritious diet rich in vitamins and minerals. And certain women may encounter hormone issues if they intermittent fast for days on end — they may benefit from intermittent fasting only a few days a week rather than every day, for example.

Additionally, if you have gallstone disease, fasting may actually increase the risk of gallbladder problems and should be avoided.

Finally, studies show that fasting may alter the levels of your thyroid hormones. If you suffer from any thyroid issues, you may want to reconsider intermittent fasting to avoid alterations in these important hormones.

If you’re physically active, intermittent fasting and working out is okay. While you can exercise during fast days, don’t push yourself too hard and remember to drink plenty of water. If you’re fasting for longer than 72 hours, however, it’s advisable to limit physical activity.

Promotes Weight Loss

One of the major intermittent fasting benefits is its ability to rev up fat burning and help the pounds slide off. In fact, many people prefer intermittent fasting to traditional diets because it doesn’t require you to meticulously measure your foods and track the calories and grams consumed.

IMF results in increased fat burning and fast weight loss by forcing your body to use up fat stores as fuel. When you eat, your body uses glucose (sugar) as its primary source of energy and stores whatever is left over as glycogen in your muscles and liver.

When you don’t give your body a steady stream of glucose, it begins breaking down the glycogen to use as fuel. After the glycogen has been depleted, your body seeks out alternative sources of energy, such as fat cells, which it then breaks down to help power your body.

This is similar to the ketogenic diet, in which you deprive your body of carbohydrates and force it to use up stored fat for energy.

Another study focused on the 16/8 method of intermittent fasting showed that it significantly reduced fat mass while retaining both muscle mass and strength.

Reduces Inflammation

Inflammation is a normal immune response to injury. Chronic inflammation, on the other hand, can lead to chronic disease. Some research has even linked inflammation to conditions like heart disease, diabetes, obesity and cancer.

A study published in Nutrition Research followed 50 individuals observing Ramadan and showed that they had decreased levels of some inflammatory markers during Ramadan fasting. Another study in 2015 found that a longer duration of nighttime fasting was associated with a decrease in markers of inflammation. In the journal Rejuvenation Research, alternate-day fasting helped reduce markers of oxidative stress.

While more research is needed, these studies provide promising evidence showing that IMF may help reduce inflammation and fight off chronic disease.

Keeps Your Heart Healthy

One of the most impressive intermittent fasting benefits is its favorable effect on heart health. Studies show that intermittent fasting improves your heart health by lowering certain heart disease risk factors.

In one study, fasting was shown to influence several components of heart health. It increased good HDL cholesterol and decreased both bad LDL cholesterol and triglyceride levels.

One animal study in the Journal of Nutritional Biochemistry showed that intermittent fasting caused an increase in levels of adiponectin. Adiponectin is a protein involved in the metabolism of fat and sugar that may be protective against heart disease and heart attacks.

In fact, in one study, rats who fasted every other day were nearly 66 percent more likely to survive a heart attack than those on a normal diet.

Article source: http://q13fox.com/2018/05/23/healthy-living-intermittent-fasting/

Healthy Living: May 22, 2018

BANGOR, Maine (WABI) - The U.S. Food and Drug Administration today approved Luxturna (voretigene neparvovec-rzyl), a new gene therapy, to treat children and adult patients with an inherited form of vision loss that may result in blindness. Luxturna is the first directly administered gene therapy approved in the U.S. that targets a disease caused by mutations in a specific gene.

Luxturna is approved for the treatment of patients with confirmed biallelic RPE65 mutation-associated retinal dystrophy that leads to vision loss and may cause complete blindness in certain patients.
Hereditary retinal dystrophies are a broad group of genetic retinal disorders that are associated with progressive visual dysfunction and are caused by mutations in any one of more than 220 different genes. Biallelic RPE65 mutation-associated retinal dystrophy affects approximately 1,000 to 2,000 patients in the U.S. Biallelic mutation carriers have a mutation (not necessarily the same mutation) in both copies of a particular gene (a paternal and a maternal mutation). The RPE65 gene provides instructions for making an enzyme (a protein that facilitates chemical reactions) that is essential for normal vision. Mutations in the RPE65 gene lead to reduced or absent levels of RPE65 activity, blocking the visual cycle and resulting in impaired vision. Individuals with biallelic RPE65 mutation-associated retinal dystrophy experience progressive deterioration of vision over time. This loss of vision, often during childhood or adolescence, ultimately progresses to complete blindness.

Luxturna works by delivering a normal copy of the RPE65 gene directly to retinal cells. These retinal cells then produce the normal protein that converts light to an electrical signal in the retina to restore patient’s vision loss. Luxturna uses a naturally occurring adeno-associated virus, which has been modified using recombinant DNA techniques, as a vehicle to deliver the normal human RPE65 gene to the retinal cells to restore vision.

Luxturna should be given only to patients who have viable retinal cells as determined by the treating physician(s). Treatment with Luxturna must be done separately in each eye on separate days, with at least six days between surgical procedures. It is administered via subretinal injection by a surgeon experienced in performing intraocular surgery. Patients should be treated with a short course of oral prednisone to limit the potential immune reaction to Luxturna.

The safety and efficacy of Luxturna were established in a clinical development program with a total of 41 patients between the ages of 4 and 44 years. All participants had confirmed biallelic RPE65 mutations. The primary evidence of efficacy of Luxturna was based on a Phase 3 study with 31 participants by measuring the change from baseline to one year in a subject’s ability to navigate an obstacle course at various light levels. The group of patients that received Luxturna demonstrated significant improvements in their ability to complete the obstacle course at low light levels as compared to the control group.
The most common adverse reactions from treatment with Luxturna included eye redness (conjunctival hyperemia), cataract, increased intraocular pressure and retinal tear.
The FDA granted this application Priority Review and Breakthrough Therapy designations. Luxturna also received Orphan Drug designation, which provides incentives to assist and encourage the development of drugs for rare diseases.
The sponsor is receiving a Rare Pediatric Disease Priority Review Voucher under a program intended to encourage development of new drugs and biologics for the prevention and treatment of rare pediatric diseases. A voucher can be redeemed by a sponsor at a later date to receive Priority Review



of a subsequent marketing application for a different product. This is the 13th rare pediatric disease priority review voucher issued by the FDA since the program began.
To further evaluate the long-term safety, the manufacturer plans to conduct a post-marketing observational study involving patients treated with Luxturna.
The FDA granted approval of Luxturna to Spark Therapeutics Inc.

Article source: http://www.wabi.tv/content/news/Healthy-Living-May-22-2018-483369261.html